Molecular diagnostic platform AccordEdge system-application advantages of quadruple operation
Publish Time: 2025-03-31
With the continuous development of molecular diagnostic technology, the demand for fast, accurate and portable molecular diagnostic platforms in clinical practice, laboratory research and inspection and quarantine is increasing. As a fully automated "sample-to-answer" molecular diagnostic platform, the AccordEdge (AE) system has become an ideal choice for doctors' offices, clinics, community hospitals and small laboratories with its unique design, efficient processing capabilities and wide range of applications. In particular, the AE system-quadruple operation (AE2234) version takes into account both throughput and flexibility, and can meet the needs of most clinical environments. This article will discuss in detail the application advantages of the AE system-quadruple operation in order to provide a reference for researchers and medical workers in related fields.
The AccordEdge system uses a fully enclosed film microfluidic bag, and through an integrated design, it realizes the automation of the entire process from cell lysis, DNA/RNA purification, template elution, molecular amplification to optical detection. This design not only simplifies the operation process, but also significantly improves the detection efficiency. The system has a small footprint and is simple and easy to use, which is particularly suitable for places with limited space. More importantly, the AE system-quadruple run version supports four samples/two independent sample preparation-PCR process, and can process 1-32 samples per day, which greatly meets the needs of different clinical environments.
Application advantages
1. Easy to use: easy operation and time saving
One of the significant advantages of the AE system-quadruple run is its ease of use. Users only need to spend less than 3 minutes of manual operation to complete the setting and start of the entire detection process. This simple operation method not only lowers the technical threshold, making it easy for non-professionals to get started, but also greatly saves time and improves work efficiency. In addition, the system's built-in intelligent control software can automatically complete the subsequent detection steps without manual intervention, further simplifying the operation process.
2. POCT: No PCR laboratory required, easy for grassroots application
Traditional molecular diagnostic technology usually needs to be carried out in a PCR laboratory, which not only limits its scope of application, but also increases operating costs and complexity. As a POCT (point-of-care testing) device, the AE system-quadruple run can be used in grassroots medical institutions such as doctors' offices, clinics or small laboratories without a dedicated PCR laboratory. This not only makes testing more convenient and efficient, but also promotes the popularization and application of molecular diagnostic technology in primary care.
3. Fast TAT: shorten reporting time and improve diagnosis and treatment efficiency
Another important advantage of the AE system-quadruple operation is its fast detection time (Turn-Around Time, TAT). From sample collection to result reporting, the entire process takes only 45 minutes. This rapid detection capability is particularly important for emergency patients and cases requiring emergency treatment. It not only helps doctors make timely diagnoses and formulate effective treatment plans, but also reduces patients' waiting time and improves diagnosis and treatment efficiency.
4. Multiple detection: improve detection efficiency and reduce costs
The AE system-quadruple operation supports multiple detections, and one test can detect more than 16 pathogens at the same time. This multiple detection capability not only improves detection efficiency, but also reduces the detection cost of a single sample. Through one test, doctors can fully understand the patient's pathogen infection, avoiding the tediousness and cost of multiple single tests. In addition, multiple tests also help to differentiate and exclude other potential infections, providing strong support for precision treatment.
5. Accurate and sensitive: ensuring the quality of laboratory testing
AE System-Quadruple Run uses advanced molecular diagnostic technology and quality control methods during the design and manufacturing process to ensure the accuracy and sensitivity of the test results. The system's built-in amplification and detection modules can efficiently and accurately amplify the target DNA/RNA fragments, and perform real-time fluorescence monitoring through the optical detection module. This high-precision detection method not only improves the accuracy of the test, but also enables the system to detect extremely low concentrations of pathogens, thereby avoiding missed diagnosis and misdiagnosis.
6. No pollution: a completely closed process to ensure biosafety
AE System-Quadruple Run uses a fully closed film microfluidic bag for sample processing. The bag does not need to be opened during the entire process, avoiding cross-contamination between samples and laboratory environmental contamination. This completely closed processing method not only ensures biosafety, but also reduces the risk of exposure to operators. In addition, the system's built-in waste disposal module can automatically handle discarded samples and reagents, further reducing the risk of environmental contamination.
Test menu
AE System-Quadruple Run has developed a series of test menus for different pathogens and diseases with its wide range of applications and efficient detection capabilities. These test menus include but are not limited to:
Respiratory pathogen detection: ingeDx AE Flu A/B, ingeDx AE Flu A/B CoV-2, ingeDx AE CoV-2 RSV, etc., for detecting respiratory pathogens such as influenza virus, new coronavirus, respiratory syncytial virus, etc.
Sexually transmitted infection (STIs) detection: OriGyn AE HPV, OriGyn AE HSV 1/2, OriGyn AE TP, etc., for detecting sexually transmitted pathogens such as human papillomavirus, herpes simplex virus, and syphilis spirochetes.
Gastrointestinal pathogen detection: ingeDx AE Norovirus, ingeDx AE Rotavirus, etc., for detecting gastrointestinal pathogens such as Norovirus and rotavirus.
Other pathogen detection: ingeDx AE GBS (Group B Streptococcus), ingeDx AE Enterococcus faecalis, ingeDx AE Escherichia coli typing, etc., for detecting other common pathogens.
These test menus not only cover a variety of common pathogens, but also meet different clinical needs. Through the detection of the AE system-quadruple operation, doctors can fully understand the patient's pathogen infection and provide strong support for precision treatment.
As a fully automatic "sample to answer" molecular diagnostic platform, the AccordEdge system-quadruple operation has shown broad application prospects in clinical practice, laboratory research, inspection and quarantine, etc. with its ease of use, POCT capability, fast TAT, multiple detection capabilities, accuracy and sensitivity, and pollution-free advantages. Through continuous optimization and improvement, the AE system-quadruple operation will provide more patients with fast, accurate and efficient molecular diagnostic services, and contribute important forces to the development and progress of the medical industry.
